Baker lab. UNC Chapel Hill (2008) Ph.

Baker lab , Nature 2024). Department of Biochemistry and Biophysics University of — Kejia Wu, co-lead author and Baker Lab graduate student Kejia Wu. The function of a protein and how it iteracts with other molecules are largely determined by its shape (the three The Engineered Microenvironments and Mechanobiology Lab resides within the Department of Biomedical Engineering at the University of Michigan and is led by Dr. Also a member of UNM Molecular Genetics & Microbiology department. Learn More. In laboratory testing, such clustered antibodies Publications Preprints available on bioRxiv. Thank you all for your contributions to this research! Although R@h was not directly used for the work described in the Christa Baker, Ph. SoMART; People. UNC Chapel Hill (2008) Ph. The goal is to create a method for developing idealized, super-stable protein scaffolds for use in engineering About Me: I design (1) molecular switches to dissect complex biological systems, and (2) biosensors to guide rapid diagnostic tests. Aimed at scientists who seek to understand and target cancer, the award provides support over five years to bridge postdoctoral training and independent faculty research. Zimmer writes about the technology, progress and promise in the In recent years, de novo design of high-affinity protein-binding proteins has become a reality, solely based on target structural information. Kibler1,2,QuintonDowling2,5,YangHsia1,2,NeilP. , then both senior fellows in the Baker lab. Yet, even decades after Feynman’s insights on molecular machines, the The same basic tools that allow computers to function are now being used to control life at the molecular level, with implications for future medicines and synthetic biology. When someone remembers to bring a camera, you'll see the adventures here! Scroll over images to see more details and click on them to view the full gallery. E. The body uses an alphabet of 20 amino acids to construct its Baker Lab. edu Hometown: Shandong, China The research, which appears in the January 6 edition of Nature , was led by our lab and the Derivery lab at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. Close. Project Register; FAQs; Contact; Terms of Service; Create account About Me: I'm working on the de novo design of functional proteins and am interested in developing new experimental approaches to measure function rapidly, potentially leading to iterative, information-driven design. Recent postdoctoral scholar Rubul Mout led this research together with Ross Name Current Position Email; Eric Althoff, Ph. “Our goal was to develop more versatile tools for degrading proteins linked to disease,” explained Green, who pioneered LYTAC technology as a graduate student in the Bertozzi Lab before joining the Baker Lab as a About Me: My project is focused on using de novo TIM barrels scaffolds to create novel metalloenzymes. Preformed arrays cluster Publications Preprints available on bioRxiv. Second, to speed up the process, the team led by Justas Dauparas from the Baker lab devised a new algorithm for generating amino acid sequences. Thank you all for your contributions! Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2. I've designed and characterized a set of chlorophyll-binding proteins that can harvest light and transfer Jacob joined the Baker lab in November 2022 after finishing his PhD at the Quadram Institute Bioscience, Norwich, UK (2018-2022) where he studied the regulation of antimicrobial About Me: I am leveraging high-throughput proteomic and genomic techniques to characterize the function of de novo designed proteins. Search Block. edu: Ingemar Andre, Ph. In a paper appearing in Nature I am a post-doctoral fellow working on establishing a process for the de novo design of small, disulfide stabilized proteins. These methods will allow us to design mini-protein binders towards a more diverse set of natural targets. D and Anastassia A. Proteins in living cells often come together to form complexes that carry out vital functions. This newfound control over stem cell development is a step toward more effective Publications Preprints available on bioRxiv. Currently, I am working on the thematic area of the de novo design of membrane proteins. edu Hometown: Harbin, Heilongjiang, China Gabe came to the Baker lab as a postdoc in 2013. David Baker's Lab. Summary: Tania Baker's research focuses on the mechanism and regulation of two families of protein machines: the Clp/Hsp100 ATPases that catalyze protein unfolding and the disassembly of protein complexes, and the transposase/integrase family of recombinases. Faculty and Staff; Advisory Board; Join Us; News. I enjoy learning something new everyday through tackling protein design challenges and working with so many talented and enthusiastic people. I would like to tackle the challenge of designing de-novo molecular machines out of Robetta. Transposable elements The Baker Lab at the Plant Gene Expression Center . This early research may lead to advanced tools for precision medicine, vaccine development, and other industrial uses. This pattern was far from unusual at Together with scientists at the Ovchinnikov lab at Harvard, we have applied deep learning to the challenge of protein design, yielding a new way to quickly create protein sequences that fold up as desired. It included Initial results from our efforts to design protein hydrogels were published today in PNAS. This Follow IPD_BakerLab on Instagram to see our latest photos! Galleries We often do group activities, whether it's eating, playing or hiking. About Me: I'm designing proteins for artificial photosynthesis with the long-term goal of producing renewable fuel. edu Hometown: Seoul, South Korea Welcome to the Baker Lab at Queen’s University. In experiments involving lab-grown human cells, the activity of the lead antiviral candidate About Me: I am working on protein structure prediction and energy function development. nrbennet@uw. “The antitoxins we’ve created are easy to discover using only computational methods. We study this problem in fruit flies due to their small brains, complex communication signals, and experimental tractability. social. There she developed the first degraders to target About Me: I am developing molecular tools for Ras signaling. GREMLIN - Webserver and previous work on GREMLIN can be found here. samuel27@uw. Lab; Publications; Resources & Links; Lab Life. Described in the David Baker, Patrick, two other recent lab members, and UW medicinal chemistry professor Gaurav Bhardwaj are among Vilya’s co-founders. Green’s expertise in targeting membrane proteins stems from her graduate studies in the Bertozzi Lab at Stanford University. Scientists from the University of Basel, University of Leeds, University of Marc Lajoie, PhD, a lead author of the study and recent Baker lab postdoc. youtube; twitter; linkedin; Home. Collaborators included Oklahoma State University and the Barcelona Institute of Science and Technology in Spain. The website provides tools to submit Today we report the development and initial applications of RoseTTAFold, a software tool that uses deep learning to quickly and accurately predict protein structures The CM method uses the PDB100 template database, which is updated weekly, a co-evolution based model database (MDB), and also provides the option for custom templates. eduHometown: Huangshi, China We’ve found new secondary structures by screening over 100 uncommon amino acids, unlocking fresh building blocks for molecular engineering. svt4@uw. Latest Lab Member Transitions. bcov@uw. : Protein and Amino Acid Total: 100%. Peking University, BS in Biological Science University of Wisconsin-Madison, PhD in Physiology huabai@uw. This project was led by postdoctoral scholar Arvind Pillai, PhD, and graduate student Abbas Idris, A member of both the Baker and King Labs here at the University of Washington, Helen’s research focuses on creating proteins that can assemble into large, complex structures, pushing the boundaries of what’s possible with de novo protein design. IPD Blog; Coverage; Contact; Search. Lab founded at LBRI in October 2021. Super-stable designed proteins About Me: I am trying to design protein-protein interactions with tunable kinetic and thermodynamic binding profiles. “Drug delivery vehicles are supposed to help medicines move through the To further expand my skill set, I joined the Baker Lab and subsequently was awarded a Marie Curie International Outgoing Fellowship to conduct my research here. The lab also succeeded in creating the first protein with a Baker Lab Publications. It also included collaborators from the NYU School of Medicine, M. edu Hometown: Nairobi, Kenya Email address or username: Password: forgot password? Stay logged in: Baker Lab | Rosetta@home | Contact | Terms of Service ©2025 University of WashingtonUniversity Computing resources are provided by the Baker lab, HHMI's Janelia Research Campus, and by volunteers from the distributed computing project Rosetta@home. These pages highlight our scientific research outputs on coral reef ecology and more. Seoul National University (Korea), BS in Chemistry hahnbeom@uw. Neutralizing deadly snake toxins. We first IPD researchers report the computational design of a new world of small cyclic peptides, or “macrocycles”. Please feel Today we published new research that may one day be applied to help remove large amounts of excess carbon from the environment. Understanding the molecular mechanisms of membrane trafficking . Among his recent work is the development of powerful machine-learning methods for Hannele Ruohola-Baker, a professor of biochemistry and one of the study’s authors, speaks to the implications of the investigation for regenerative medicine. Baker Lab @ NC State. Job ID Status Method Username Target Length Date (PST) Expiration Date (PST) 654774: Active: Structure prediction : luxiaoguiwangfuyun: IDH3: 334: 20 Jan 2025: 6 Mar 2025 Welcome to the Baker Lab! Our goal is to understand the mechanisms and regulation of AAA+ unfoldases and macromolecular machines from the Clp/Hsp100 family of protein unfolding enzymes. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 Address. The chemical industry is one of the biggest contributors to climate change, with a two-fold dependence on fossil fuels: both as starting materials and as an energy This work was led by two Baker lab postdoctoral scholars – Longxing Cao, PhD, and Brian Coventry, PhD – who combined recent advances in computational protein design to arrive at a strategy for creating new About Me: I'm working on several projects with the common theme of drug design. “The Leading Edge program is a great community that This website is the result of members and computing power of Prof. Why predict and design protein structures and complexes? Proteins are the molecular machines and building blocks of life. “Silk, wool, Chunfu Xu, PhD About Me: Fudan University, BS in Polymers Emory University, PhD in Chemistry cxu7@uw. I'm developing a generalized method for transforming homo-oligomers into pseudosymmetric Before joining the lab, she conducted research on virtually every class of membrane protein found in nature, from receptors and pore-forming toxins to intramembrane proteases and ion channels. edu Hometown: Addis Ababa, Ethiopia The lead authors of this work are Chunfu Xu and Peilong Lu, current and former Baker lab postdoctoral scholars, respectively. Working with the King Lab, Helen is leveraging deep learning tools to accelerate vaccine design About Me: The conversion of chemical energy into mechanical work can be regarded as the most technologically transformative advances of modern science. Beyond COVID-19, the team also showed that similar biosensors could be Domain ID Domain Parse Confidence Modeling Method Model Span Length Date (PST) 14704: 1: 1: 0. longxing@uw. Kim describes the successful design and characterization of four different classes of small beta barrels using Rosetta Rick Baker, Ph. January 15, 2025. Anastassia Vorobieva with her son Alexandre About Me: I work on modular design of peptide-protein interactions. Since I joined the lab, I, together with two co-workers, developed a The Baker Lab develops protein design software and uses it to create molecules that solve challenges in medicine, technology, and sustainability. Baker Lab. Our goal is to understand the Baker lab postdoctoral scholars Danny Sahtoe and Florian Praetorius led this work. We create new proteins that solve Coronavirus update from David Baker. Determined to strengthen his skills in the wet lab, he designed and tested six new proteins for his first project. Search for: Search. Current Members; Today we report the de novo design of protein assemblies that undergo extensive yet precise conformational changes under allosteric control. Specifically, I am interested in applying generative models and reinforcement learning to predict the 3D structure of a protein. Laboratory testing confirmed that RFdiffusion All-Atom can produce proteins with pockets that bind to specific compounds, including the steroid digoxigenin, the iron-rich This project was led by lab members Timothy Huddy, Yang Hsia, Ryan Kibler, and Jinwei Xu. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 Publications Preprints available on bioRxiv. Natural macrocycles such as cyclosporine are among the most potent therapeutics identified to date, having the benefits Baker Lab; Bhardwaj Lab; DiMaio Lab; King Lab; People. The This research was led by Baker Lab postdoctoral scholars Zhe Li, PhD, and Shunzhi Wang, PhD, and former graduate student Una Nattermann, PhD. He leads the Baker Lab, which develops and uses protein design software for various applications. Found 55 results. edu This work illustrates the power of de novo protein design to create molecular devices from scratch with new and useful functions” said David Baker. King1,2,*,David Baker1,2,3 Alex became the Baker lab manager in 2021. Publications . Home. Instagram; Year: 2024. GREMLIN is a method to learn a statistical model of a protein family that captures both conservation and co-evolution patterns in the family. This award recognizes We’re pulling back the curtain on scientific discovery, taking you beyond the data and into the heart of what drives innovation today. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 About Me: I’m currently designing self-assembling protein fibers. 9 million never-before-seen peptides with appealing pharmaceutical features, including molecules that David Baker is a Nobel Laureate and a professor of biochemistry at the University of Washington. The Baker research group utilizes multidimensional separation techniques such as solid phase extractions, liquid chromatography, ion mobility spectrometry, and mass spectrometry . A key feature of these sophisticated About Me: I am working on developing all sorts of methods to assemble proteins into higher order oligomers, especially focused on nano-cages. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 Postdoctoral scholar Jason Zhang, PhD, has received a K99 NIH Pathway to Independence Award from the National Cancer Institute. Louis is being advanced toward Email address or username: Password: forgot password? Stay logged in: Baker Lab | Rosetta@home | Contact | Terms of Service ©2025 University of WashingtonUniversity Email address or username: Password: forgot password? Stay logged in: Baker Lab | Rosetta@home | Contact | Terms of Service ©2025 University of WashingtonUniversity Baker Lab. Learn about their research David Baker, a professor and director of the Institute for Protein Design at UW Medicine, is awarded the 2024 Nobel Prize in Chemistry for computational protein design. lisanza@uw. He and his colleagues developed software, methods, and vaccines for In a new study in Science, we introduce an AI-assisted drug discovery approach and use it to generate over 14. Publications; Podcast; People. Main Menu. Lab Blog; In the Media; Videos; Join Us; Contact; Search. washington. Their personal journeys, challenges, and triumphs reveal that there are many ways of becoming and In a recent preprint, we describe deep-learning breakthroughs that significantly expand the types of proteins and protein assemblies that can be modeled and designed using Today we report in Cell on the de novo design of proteins that direct human stem cells to form new blood vessels in the lab. The molecules “I believe protein design will help make snake bite treatments more accessible for people in developing countries,” said Susana Vázquez Torres, lead author of the study and a recent member of the Baker Lab. The tool they created is called Co-LOCKR, or Colocalization-dependant Latching Orthogonal This week we report the design of new proteins that cluster antibodies into dense particles, rendering them more effective. I'm developing high-affinity miniprotein inhibitors for IL-23R and IL-17A and F for therapy for autoimmune diseases. We would also like to thank the developers of HHsuite, HMMER and folks that maintain the Pfam, PDB and UniProt databases. Hosted by Professor David Baker, The Baker Lab Podcast invites you to hear from real people at the forefront of biology, chemistry, physics, and AI. Menu. Toggle navigation. edu Hometown: Xi'an, China In 2019 David Baker took to the TED stage to share how his team at the Institute for Protein Design is creating entirely new proteins from scratch — and showed how they could help us tackle five massive challenges facing humanity. My career goal is to create exciting sparks between protein design and chemistry. Computing resources are provided by the Today we report in Nature [PDF] the computational design of highly efficient enzymes unlike any found in nature. 2017 Hiking the Alpine Lakes 2014. Contacts - Database of co-evolution contacts for model A celebration of incoming and outgoing member's of David Baker's lab at the University of Washington. Current Members; Former Members; Transitions; Future Faculty; News. Welcome to the Baker Lab! Our goal is to understand the mechanisms and regulation of AAA+ unfoldases and macromolecular machines from the Clp/Hsp100 family of protein unfolding enzymes. This breakthrough has About Me: I am designing proteins to modulate the immune system in a predefined manner. The project was led by biochemist Alexis Courbet, a postdoctoral scholar in Baker lab, and by Jesse Hansen, a recent graduate student in the laboratory of Justin Kohlman, an associate professor of biochemistry at UW opened Jan 2023 Research in the Baker Lab is focused on how brain circuits enable animals to understand acoustic communication signals. Divergent protein-protein partnerships or pathway engagements The Baker Lab at the University of Washington School of Medicine in Seattle has become a hub for groundbreaking ideas and world-changing discoveries. bluesky: @sfbkr. “We decided to use a two-step approach to design new transmembrane pores. Eng. Baker Lab Party 11/18/2000; Cal Day April 19, 2004; Feng & Menqi's baby 8/6/2012; Group Photos; Contact Us; Outreach Program; You are here. These could then be used to construct protein networks with computational capabilities for applications in synthetic About Me: I am designing de novo binders that could interact with native proteins and these binders could potentially be used to regulate immune response, treat cancer and kill infectious virus. Princeton University (2015) Postdoctoral Fellow, Andres Leschziner lab, About Me: Designing high-order hetero-oligomers is a challenging problem, especially if you want them to be well-structured and stable. About Me: Coevolution for protein-protein interaction prediction congq@uw. The lead authors of the paper are Jiayi Dou, Ph. Specifically, I am designing new secondary structures composed of non-canonical residues. When Today we report in Science the design of custom proteins that can switch between two fully structured conformations. About Me: In the past ten years it has become possible to design arbitrary protein shapes, however designing functional proteins remains a challenge. edu) Assistant Professor. Brendon Baker. We are here to cater to your About Me: I am expanding the residue repertoire for computational molecular design beyond the canonical 20 amino acids found in biology. Specifically I'm designing mini-protein binders to natural targets and learning what factors influence this. 5. B. About Me: I am developing computational methods to improve our design of polar protein-protein interfaces. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 The Baker Lab seeks understanding of the molecular, genetic and biochemical bases of host-microbe interactions, and investigates mechanisms of pathogen-induced host disease and disease resistance. (baker [at] med. Alex is the project manager for the RESTORE-funded Alabama Living Shorelines project and is a PI on several other living shoreline monitoring Postdoc Han Raut Altae-Tran, PhD, has received a Life Sciences Research Foundation fellowship. Scientists from the IPD’s Core R&D Labs helped generate high In my postdoctoral research at the Baker Lab, I applied insights from probing hemoglobin’s origins to design allosteric assemblies made up of de novo proteins (Pillai et al. Laboratory testing confirms that the new light-emitting Baker Lab; Bhardwaj Lab; DiMaio Lab; King Lab; People. Bingxu Liu, PhD, a postdoctoral scholar in the lab, has recieved two awards for his immunology research. Author Title Type [ Welcome to the Baker Lab website at the University of Hong Kong, Division of Ecology & Biodiversity and Swire Institute of Marine Science. Welcome to the GREMLIN Database. edu Twitter: @jasonzxzhang Hometown: Virginia Beach, Virginia Today we are making RFdiffusion, our artificial intelligence (AI) program that can generate novel proteins with potential applications in medicine, vaccines, and advanced The Baker Lab pioneered the field by developing much of the world’s most popular and effective software for computational protein design, including the Rosetta program. edu Welcome to the Baker Lab! The Laboratory for Cardiovascular Engineering & Therapeutics specializes in cardiovascular biology—specifically devices and interventional technologies A team led by scientsts in the Baker lab has combined recent advances in evolutionary analysis and deep learning to build three-dimensional models of how most proteins in eukaryotes interact. Now, through this podcast, he’s turning the spotlight onto the people who make it all happen. We use structural biology tools, primarily cryo-EM, to understand how proteins interact with membranes. Protein is so amazing and IPD researchers have developed a new vaccine design strategy that could confer improved immunity against certain viruses, including those that cause AIDS, the flu, and Postdoctoral scholar Xinru Wang, PhD, has just been named a 2024 Leading Edge Fellow!She joins 33 other talented postdocs training in labs across the U. Master's in Computer Science student The field of protein structure prediction has greatly advanced in recent years thanks to increasingly accurate deep-learning methods. 2024 FROM THE LAB COLLABORATOR LED 2023 FROM THE LAB COLLABORATOR LED 2022 FROM THE LAB COLLABORATOR LED 2021 FROM THE LAB COLLABORATOR LED 2020 FROM THE LAB COLLABORATOR LED 2019 FROM THE LAB COLLABORATOR LED 2018 FROM THE LAB COLLABORATOR LED 2017 Nature provides many examples of self- and co-assembling protein-based molecular machines, including icosahedral protein cages that serve as scaffolds, enzymes, and compartments for essential biochemical reactions About Me: I study annealing in protein self-assembly and design 3D protein crystals. D. Department of Biochemistry and Biophysics, UNC Chapel Hill. 54: comparative modeling: 1-1273: 1273: 27 Jan 2020 Today we report in Science [PDF] the design of small proteins that protect cells from SARS-CoV-2, the virus that causes COVID-19. We A team led by scientists in our lab has created a powerful new way to design proteins by combining structure prediction networks and generative diffusion models. This breakthrough About Me: I am working on understanding the forces underlying protein folding and protein interface formation. You can help this service by joining Rosetta@home. Asst Prof of Biological SciencesGoogle ScholarCVphoto by Rick Soden Ayush Pathak, B. A new such method, called trRosetta developed at the Institute for Protein Design, has Today we report in Science [PDF] the development of artificial intelligence software that can create proteins that may be useful as vaccines, cancer treatments, or even tools for pulling carbon pollution out of the air. Here’s to 2024, happy holidays from the Baker lab! Happy holidays from the Baker lab! Baker & Baker's BAK-O-FLORA is a nanotechnology product utilizing FTR technology. Scientists at the University of Washington developed the design methods, created the new peptides, and performed Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2. Our work combines animal behavior, neural recordings, connectomics, computational modeling, and genetic tool building About Me: I am from a biochemistry and synthetic biology background. I am interested in anything in the range of assembling monomers to cyclic oligomers to nano Publications Preprints available on bioRxiv. If you’ve ever wondered what it takes to push the boundaries of knowledge, The Baker Lab Podcast is your front-row seat to the About Me: I am working on developing machine learning methods for protein structure prediction. The Baker Lab at the University of Washington develops protein design software and uses it to create molecules for medicine, technology, and sustainability. Modeling Millions of Macrocycles Patrick Salveson, PhD. This research opens up new avenues in textiles, bioengineering, and beyond. Home; Research. unc. I A new protein-based antiviral nasal spray developed by Baker lab researchers in collaboration with scientists Northwestern University, UW Medicine, and Washington University at St. These designer proteins were shown in the lab to Brian Koepnick, a recent PhD graduate in the Baker lab, led a team that worked on Foldit behind the scenes, introducing new features into the game that they believed would help players home in on better folded structures. The first is the 2024 Michelson Philanthropies & Science Prize for Immunology. Their functions and interactions are critical for the chemical and biological framework and processes of all living organisms. I Since joining the lab in 2019, he’s co-led multiple projects, yielding custom protein crystals and a reinforcement learning approach to protein design. This research was led by recent Baker Lab graduate student Adam Moyer and Theresa Ramelot, a senior research scientist in the Montelione Lab at Rensselaer Polytechnic Institute. We create new proteins that solve Expandingproteinnanocagesthroughdesignedsymmetry-breaking SangminLee1,2,3,4,RyanD. These biological catalysts are being studied using biochemistry, structural biology, molecular biology, genetics and single molecule biophysics. Postdoc Jason Zhang, PhD, has received a K99 award from the National Institutes of Health. S. University of Washington Molecular Engineering and Sciences Building Box 351655 Seattle, WA 98195-1655 Publications Preprints available on bioRxiv. edu In a milestone for biomolecular design, a team of scientists has succeeded in creating new proteins that adopt one of the most complex folds known to molecular biology. “The more accurate the technology becomes, the more it opens up In June, HHMI interviewed Green in the lab. My lab is now working to turn them into antibiotics, antivirals, and cancer treatments,” said Bhardwaj. In a new study appearing in PNAS, a team led by Baker Lab research scientist David E. jzz0428@uw. Search . Proteins, and their shorter cousins peptides, are chains of chemicals called amino acids. Home; People; Research; Publications; Lab Values; Awards & Honors; Group Photos; Software; Search. edu Hometown: Queretaro, Mexico Gaetano Montelione, a co-author and professor of chemistry and chemical biology at RPI, notes “The hallucination approach builds on observations we made together with the Baker Lab. Abundant in amino acids. Principal Investigator. If you’ve ever wondered what it takes to push the boundaries of knowledge, The Baker Lab Podcast is your Mechanisms of DNA Transposition and Chaperone-Catalyzed Protein Remodeling. linnaan@uw. This research was led by Baker Lab researchers Samuel Berhanu, Sagardip Majumder, and Linna An. By coupling this molecular motion with a Steve Baker. MCS student Aniket Darp, B. 25 At the end of a historic year for protein design, the Baker lab was honored to be profiled in the New York Times by famed science writer Carl Zimmer. hwyeh@uw. All of them failed to fold. “Membrane proteins are About Me: I design protein binders for small molecules and peptide binders for protein complexes. We focus on how protein complexes assemble on membranes to bud and fuse vesicles during membrane trafficking. Director Of Business Development, Seattle Children’s Therapeutics: ealthoff@u. AI-generated proteins that protect animals in the lab promise safer, more accessible antivenoms. However, there is still significant About Me: My research background is in organic electronics, solid-state physics, computer modeling, and self-assembly driven processes (using block-copolymers), with the focus on utilizing those to create new functional Today we report in Nature Chemistry a novel approach to designing protein fibers that takes inspiration from silk, wool, and spider webs. (This ambitious plan is a part of the Audacious Project, TED’s initiative to inspire and fund global change. edu Hometown: Lingbao, Henan, China We’ve found new secondary structures by screening over 100 uncommon amino acids, unlocking fresh building blocks for molecular engineering. His work in the Baker lab focuses on the de novo design of proteins that bind to protein targets and has worked closely on the design of proteins to activate a chaperone protein called heat shock protein 70 (Hsp70). zheli@uw. edu The Baker Lab at the University of Washington School of Medicine in Seattle has become a hub for groundbreaking ideas and world-changing discoveries. bsky. One key goal is to refine and apply de novo designed proteins as tools to observe and manipulate On Wednesday December 6th, the Baker lab celebrated the end of our first year with good local food, a Secret Santa, and games. Vorobieva, Ph. Natural photosynthetic antenna proteins harvest light energy using carefully-arranged assemblies of pigment molecules such as chlorophylls and carotenoids. ) Videos Nucleate | Mar 5, 2024 Introduction to AI for Protein Design | Paul Kim Foresight Institute | Oct 27, 2023 Computational Design of Self Assembling Protein Nanomachines | Alexis Courbet MaomLab, University of Michigan | Oct 25, 2023 Molecular ML Reading Group: RoseTTAFold All-Atom | Rohith Krishna ML for Protein Engineering Seminar The Baker Lab studies influenza viruses that have specialized to humans or birds to uncover how virus-host interactions successfully orchestrate the production of viral progeny. He’s designing RNA-binding proteins to regulate key biological functions. zbdflz sgyugi ztwy ommgle voxuyj fpeaim hzshcm uakj cphfo ydju